Characterization of Microfragmented Adipose Tissue Architecture, Mesenchymal Stromal Cell Content and Release of Paracrine Mediators

Abstract: The use of microfragmented adipose tissue ( FAT) for the treatment of musculoskeletal disorders, especially osteoarthritis (OA), is gaining popularity, following positive results reported in recent case series and clinical trials. Although these outcomes were postulated to rely on paracrine signals, to date, a thorough fingerprint of released molecules is largely missing. The purpose of […]

Comparison of the Effect of MFAT and MFAT + PRP on Treatment of Hip Osteoarthritis: An Observational, Intention-to-Treat Study at One Year

Hip osteoarthritis (OA) is a major contributor to reduced quality of life and concomitant disability associated with lost working life months. Intra-articular injection of various biological materials has shown promise in alleviating symptoms and potentially slowing down the degenerative process. Here, we compared the effects of treatment of a cohort of 147 patients suffering from […]

Micro-fragmented adipose tissue regulated the biological functions of osteoarthritis synoviocytes by upregulating MiR-92a-3p expression

Abstract Apart from the treatment potential of micro-fragmented adipose tissue (MF) in joint diseases, what’s less clear is the mechanism of MF on Osteoarthritis (OA). Synoviocytes isolated from synovium tissues of 11 knee joint OA patients were identified and co-cultured with MF collected by Lipogems®. Cytokines and mRNA levels in synoviocytes were detected by enzyme-linked […]

Intra-Articular Injection of Autologous Microfat and Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Double-Blind Randomized Comparative Study

Abstract Purpose: To compare a single abdominal microfat (MF) injection mixed or not with platelet-rich plasma (PRP) Low Dose (LD) or High Dose (HD) in order to improve MRI parameters, alleviate pain and enhance functional capacity in knee osteoarthritis. Methods: Patients with symptomatic grade 2 to 4 knee osteoarthritis according to the International Cartilage Repair Society MRI […]

Safety and Feasibility of Autologous Micro-Fragmented Adipose Tissue Injections for the Treatment of Vaginal Atrophy, Vulvovaginal Dystrophy, and Stress Urinary Incontinence: An Observational Case Series

Abstract  Objective: Vaginal atrophy, vulvovaginal dystrophy, and stress urinary incontinence (SUI), common conditions in women, have detrimental effects on quality of life. Current treatments require ongoing use and are associated with risks, complications, and incomplete resolution of symptoms. The aim of this observational case series was to evaluate the safety and feasibility of autologous micro-fragmented […]

Microfragmented Adipose Tissue Injection (MFAT) May Be a Solution to the Rationing of Total Knee Replacement: A Prospective, Gender-Bias Mitigated, Reproducible Analysis at Two Years

In this work, Heidari et al, analysed the 24-month outcome from a cohort of 344 patients, suffering from grade 3-4 (moderate to severe) knee osteoarthritis, [many of whom were on the waiting list for total knee replacement], following a single, ultrasound-guided injection of micro-fragmented adipose tissue into the affected joint. A comparison of pre-operational and […]

Comparative Evaluation of the Clinical Efficacy of PRP-Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia

Abstract Platelet-rich plasma (PRP) therapy has been considered as a promising treatment for androgenetic alopecia (AGA). The aim of the study was comparative evaluation of the clinical efficacy of PRP-therapy, minoxidil, and their combination in the treatment of men with AGA and to evaluate the effects of PRP on the proliferation of hair follicle (HF) […]

Characterisation of Novel Angiogenic and Potent Anti-Inflammatory Effects of Micro-Fragmented Adipose Tissue

In this work, the authors performed a detailed in vitro characterization of the biological properties of micro-fragmented adipose tissue (MFAT) obtained from eight volunteers who underwent liposuction and provided material generated using the Lipogems device. MFAT cluster size varied from sample to sample with 51-76% being within the expected range of 0.3-0.75mm. Conditioned medium obtained […]

A pilot study to evaluate micro-fragmented adipose tissue injection under ultrasound guidance for the treatment of refractory rotator cuff disease in wheelchair users with spinal cord injury

In this single group pilot study, a series of  10 wheel-chair users with chronic moderate-to severe shoulder pain caused by refractory rotator cuff disease received an ultra-sound guided intra-articular injection of Lipogems-derived micro-fragmented adipose tissue (MFAT) and were monitored for pain, adverse events and also by ultrasound over a 12 month period. The study showed […]